I viewed one Super Bowl ad that contained a vaguely weird natural history angle in it.  (Yes, also, there was a Sasquatch this year. See here.)

The following Mayan 2012 Apocalptic ad was strange:

Near the end of its one minute you can spot a Fortean fall.

No doubt this is inspired by this scene from Magnolia, over at YouTube (embedding was disabled).

Frog from Magnolia, on exhibit at the International Cryptozoology Museum.